The hosts said their decision followed West's controversial statements about slavery, adding the hashtag #MuteKanye.
On Tuesday, West appeared at TMZ's headquarters, where he said: "When you hear about slavery for 400 years ... For 400 years? That sounds like a choice."
During the Thursday morning radio show, Shay Shay also called West "reckless" for saying icons like Martin Luther King, Jr. and Malcolm X are "too far in the past and not relatable."
The Detroit hip-hop station is not alone.
On Wednesday, New York City radio host Ebro Darden appeared on CNN Tonight with Don Lemon to discuss West's comments, where Lemon said the rapper "doesn't know history."
The next morning, Hot 97, where Darden's show airs, tweeted, "'The Kanye boycott has begun.'"